This study investigated the relationship and interactions between compassion fatigue and anticipatory traumatic reaction (ATR), both conditions arising from secondary exposure to trauma. Compassion fatigue, which often occurs for caring professionals, involves symptoms of secondary traumatic stress and job burnout. ATR is a future-focused form of distress arising from media reports and social discussions of large-scale negative events and threats. A cohort of 48 youth workers from a not-for-profit company located in the New England region completed measures of secondary traumatic stress, burnout, compassion satisfaction, general distress, and anticipatory traumatic reaction. Surveys were completed via the online Qualtrics platform. Results showed that ATR magnified the relationship between secondary traumatic stress and general distress. Moderated mediation analyses indicated that anticipatory traumatic reaction interacted with general distress in connecting secondary traumatic stress with burnout. High levels of ATR may exacerbate distress, potentially putting care workers at greater risk of burnout.