Because meaning is fundamental to language and culture, a practical technique for describing meanings and transposing them across languages has multiple practical applications. This chapter demonstrates several applications of the NSM approach to semantics: as a guide to core vocabulary in the early L2 syllabus, as a means of writing cultural scripts and interpreting cultural key words for language learners, and as the basis for a culture-neutral international auxiliary language. Illustrative material is drawn from English, Russian, and Korean.