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Title
Combining two markov chain monte carlo approaches for linkage and association studies with a complex pedigree and multi marker loci
Fields of Research (FoR) 2008:
Publication Date
2005
Socio-Economic Objective (SEO) 2008
Abstract
In QTL mapping using linkage and/or linkage disequilibrium, an important process is to find the pattern of inheritance states and haplotype configurations, a process known as haplotype reconstruction. Haplotype reconstruction is routinely based upon observed pedigree information and marker genotypes for individuals in the pedigree. It is not feasible for the exact methods to use all such information for large complex pedigree especially when there are many missing genotypes. Markov Chain Monte Carlo (MCMC) approaches have been widely used to handle a complex pedigree with sparse genotypic data. However they often have reducibility problems or are slow to converge. Combining two different MCMC approaches results in improvement of computational speed and mixing properties. It allows obtaining reliable estimates such as identity by descent coefficients between individuals within a reasonable time.
Publication Type
Conference Publication
Source of Publication
Proceedings of the Association for the Advancement of Animal Breeding and Genetics, v.16, p. 107-110
Place of Publication
Collingwood, Australia
ISSN
1328-3227
Peer Reviewed
Yes
HERDC Category Description
ISBN
064309234X
0643092331
Peer Reviewed
Yes
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