Alcohol consumption can induce the development of nutritional disorders as alcohol ingestion often replaces food intake [1]. The long-term intake of alcohol decreases the amount of food consumed when food is freely available [2], and the degree of malnutrition may be related to the irregularity of feeding habits and intensity of alcohol intake [3]. The repercussions of alcohol abuse (over time) can involve damage to most of the major organs and systems in the body [4]. However, despite the overwhelming evidence linking alcohol to ill health the role (if any) alcohol plays in the development of disease remains uncertain. The hypothalamic-pituitary-adrenal (HPA) axis is responsible for the synthesis and release of steroid hormones, the most abundant being dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), cortisol, and aldosterone [e.g. 5]. The release of either corticotropin-releasing factor or arguinine vasopressin by the hypothalamus stimulates the anterior pituitary to release adrenocorticotropin (ACTH), which promotes the synthesis and release of steroid hormones that have glucocorticoid (i.e. cortisol), mineralocorticoid (i.e. aldosterone), and androgenic (i.e. DHEA, DHEAS) functions [6]. Steroid hormones have a diverse and highly important role in the body and any dysregulation in steroid activity can lead to the development of disease. The adrenocortical system is markedly altered by food availability and an elevation in cortisol is commonly observed under fasting conditions [7-9]. Cortisol plays a major role in the regulation of carbohydrate, protein, and lipid metabolism [10,11] and during prolonged fasting by stimulating gluconeogenesis acts to protect the body from cellular damage until food once again becomes available [7,8,10-14]. ... The aim of this study was to clarify the effect (if any) of consuming a small-moderate amount of white wine on cortisol by comparing the effect (if any) of consuming a small-moderate amount of white wine on salivary cortisol and serum cortisol, and salivary cortisol alone.