This study comprehends how non-pharmaceutical approaches such as “quarantine,” “social distancing,” and “lockdown” help to impede the extent of the severe COVID-19 pandemic. The abrupt, surfacing, and evolving circumstance of this infection was thought to be defended, imperative, and implemented through these approaches as a core component of the quick response in the arena of a global health emergency. In this pursuit, a logical conceptual framework is developed using a qualitative method by reviewing literature along with analyzing numerous documents and reports. Based on information from some countries, this exploration centers around significant approaches and the embraced socio-health policy used as a preventive framework leading to the quarantine, social distancing, and lockdown for the transmission of the virus headed for the community. Studies have shown that populations flowing from the sources of the outbreak pose a higher level of risk in the destination area than other factors such as topographical vicinity, physical contact, and interaction. This study, therefore, suggests some draconian socio-health policies to be imposed, such as quarantine, social distancing, and lockdown measures to cripple the transmission of the virus. The sooner such measures are implemented, the shorter will be the term of the endemic. Finally, the findings have important implications for the policymaking to be adopted globally as well as nationally preventive strategies.