The western region of Kenya is experiencing remarkable land changes resulting from population growth and related impacts. The study used remote sensing and GIS techniques to analyze the land use/cover changes in the years 1995, 2001, 2010 and 2017. Multi-spectral Landsat (TM, ETM + and OLI) images were pre-processed and classified using maximum likelihood algorithm in ENVI version 5.4. The overall classification accuracies in all the images were more than 80%. The results revealed major conversions of each land use/land cover type in varying trends and magnitudes. Between 1995 and 2001, there was an increase in built-up areas by 71%, forest cover by 43%, farms by 5%; and decrease in grassland by 47%. By 2017, the built-up areas had increased by 225% and farms by 17%; the forestland, grassland and water reduced by 38, 10 and 11%, respectively. The observed changes are characterized by increased settlements and encroachment of sensitive ecosystems.