Irrigated agriculture requires high reliability from water delivery networks and high flows to satisfy demand at seasonal peak times. Aquatic vegetation in irrigation channels are a major impediment to this, constraining flow rates. This work investigates the use of remote sensing from unmanned aerial vehicles (UAVs) and satellite platforms to monitor and classify vegetation, with a view to using this data to implement targeted weed control strategies and assessing the effectiveness of these control strategies. The images are processed in Google Earth Engine (GEE), including co-registration, atmospheric correction, band statistic calculation, clustering and classification. A combination of unsupervised and supervised classification methods is used to allow semi-automatic training of a new classifier for each new image, improving robustness and efficiency. The accuracy of classification algorithms with various band combinations and spatial resolutions is investigated. With three classes (water, land and weed), good accuracy (typical validation kappa >0.9) was achieved with classification and regression tree (CART) classifier; red, green, blue and near-infrared (RGBN) bands; and resolutions better than 1 m. A demonstration of using a time-series of UAV images over a number of irrigation channel stretches to monitor weed areas after application of mechanical and chemical control is given. The classification method is also applied to high-resolution satellite images, demonstrating scalability of developed techniques to detect weed areas across very large irrigation networks.